https://www.challengeunit.ca/blog daily 0.75 2025-10-09 https://www.challengeunit.ca/blog/pertussis-challenge-study monthly 0.5 2022-10-28 https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/3332e7da-9564-475b-8787-da6dbb54f682/Blog+header+images+%285%29.png Further Reading - The problem with pertussis, and how a human challenge trial could help - Make it stand out Pertussis, also known as whooping cough, is a contagious disease caused by a type of bacteria called Bordetella pertussis. Symptoms can be more serious, and even deadly, in infants. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/dcda2cea-d12e-448e-8d09-d74ac5654c56/Blog+header+images+%287%29.png Further Reading - The problem with pertussis, and how a human challenge trial could help - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/36f753a4-d168-4c09-ac51-8cd144e5cbd8/Blog+header+images+%288%29.png Further Reading - The problem with pertussis, and how a human challenge trial could help - Make it stand out When the people around an infant are mostly vaccinated, the community immunity helps protect the more vulnerable child. This is harder to achieve with pertussis, as immunity wanes very quickly - sometimes within two years. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/8907ea62-d166-45e0-baf4-ad16e826f582/CHIM+blog+photo+-+Blood+pressure.png Further Reading - The problem with pertussis, and how a human challenge trial could help - Make it stand out A human challenge trial lets us observe how the human immune system responds to pertussis in the earliest stages of exposure. Researchers can collect daily samples to better understand how the bacteria that causes the disease is acting in the body. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/cea77670-4615-4977-8e88-f6050da2c05d/CHIM+photos+%282%29.png Further Reading - The problem with pertussis, and how a human challenge trial could help - Make it stand out Healthy, informed, consenting participants will be intentionally exposed to pertussis in a controlled environment, then monitored by healthcare staff during an inpatient stay in CCfV’s fully-equipped challenge unit. https://www.challengeunit.ca/blog/case-study-pneumonia monthly 0.5 2022-08-08 https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/7734c6ca-bc08-4b22-9f51-465d14cf3755/CHIM+Case+Study+-+Pneumonia+-+Infographic.png Further Reading - Human Challenge Trial Case Study: Pneumonia - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.challengeunit.ca/blog/challenge-trial-impacts monthly 0.5 2022-06-16 https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/02f3bb23-25d1-41b6-9b93-d9fe6fedf2b1/Blog+header+images+%282%29.png Further Reading - Local research with global impacts – human challenge trials making a difference - Make it stand out What we learn from human challenge trials can push us closer to finding better methods of protecting against disease, like improved vaccines. The impacts reach around the world. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/9e2e97c3-8eb0-4da2-8e25-832fd2062a75/Blog+header+images+%281%29.png Further Reading - Local research with global impacts – human challenge trials making a difference - Make it stand out The flu can be a more serious illness for seniors, the very young, or those with certain health conditions. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/5d9a98b4-b603-4755-90a6-9001d8717faa/freedom-9PRZ4T6.jpg Further Reading - Local research with global impacts – human challenge trials making a difference - Make it stand out Human challenge trials and the volunteers that take part in them will continue to make a difference felt in our communities and around the world. https://www.challengeunit.ca/blog/volunteers-are-vital monthly 0.5 2022-06-20 https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/6e0ea2ac-0ce9-4de3-bf6b-dd32ab14aa0c/CHIM+Blog+Header+3.png Further Reading - Volunteers are vital. How does a human challenge trial ensure their safety? - Make it stand out Volunteers are a vital part of every clinical study. The participant experience and participant safety are the most important parts of study design. Human challenge trials are no different. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/23101665-684e-4120-8ad6-7c022b330731/CHIM+Blog+photo+-+young+and+elderly.png Further Reading - Volunteers are vital. How does a human challenge trial ensure their safety? - Make it stand out Challenge trials only recruit participants who aren’t at risk of serious or severe complications from the infection or treatments. This typically excludes the elderly or very young. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/fb457e7c-236a-4593-a59b-7fe38d9875cf/Untitled+design+%285%29.png Further Reading - Volunteers are vital. How does a human challenge trial ensure their safety? - Make it stand out Like a hospital stay, participants in human challenge trials are closely monitored for symptoms. Healthcare support is available around the clock if needed for any reason. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/feba3fb8-a16b-41d0-9bfc-a73760c7a141/CHIM+Blog+photo+-+Informed+Consent.png Further Reading - Volunteers are vital. How does a human challenge trial ensure their safety? - Make it stand out Informed consent is crucial to an ethical clinical study. Volunteers must understand what they are being asked to do, before agreeing to take part. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/24b194d1-b08f-40f0-ba80-32b75a718950/Untitled+design+%286%29.png Further Reading - Volunteers are vital. How does a human challenge trial ensure their safety? - Make it stand out Human challenge trials often take place in specialized inpatient facilities like CCfV's Challenge Unit, pictured here. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/59587329-5a6d-48ee-8eaa-f95268440790/Untitled+design+%287%29.png Further Reading - Volunteers are vital. How does a human challenge trial ensure their safety? - Make it stand out Some past participants in human challenge trials have used their time in the facilities to do remote work. https://www.challengeunit.ca/blog/answering-questions-about-disease monthly 0.5 2022-06-20 https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/b9a1750a-9c64-4308-b350-64497c38b5fe/CHIM+Blog+Header+2.png Further Reading - Answering tough questions about disease with human challenge trials - Make it stand out Though other study methods play an important role in advancing vaccines and treatments, human challenge trials have some advantages that can help us find the answers to longstanding questions about disease. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/e44e9889-24f4-4e9b-9079-65521ef4e38a/CHIM+Blog+photo+-+Transit+bus.png Further Reading - Answering tough questions about disease with human challenge trials - Make it stand out Clinical trials are typically outpatient. Influences from a participant's day-to-day life (like catching another disease) could affect the data collected for the study. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/d384c3f8-e036-4151-8a20-b1df2ae790dc/Untitled+design+%284%29.png Further Reading - Answering tough questions about disease with human challenge trials - Make it stand out Human challenge trials intentionally expose participants to disease at a planned time and place. They don't have to wait for a certain number of participants to become sick in day-to-day life. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/8907ea62-d166-45e0-baf4-ad16e826f582/CHIM+blog+photo+-+Blood+pressure.png Further Reading - Answering tough questions about disease with human challenge trials - Make it stand out In a challenge trial, researchers know for sure that participants will encounter the pathogen and can collect more data with scheduled daily tests – providing more complete data than other types of studies. https://www.challengeunit.ca/blog/challenge-trials-overview monthly 0.5 2022-06-20 https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/1c73c8f0-4692-4b3f-ade6-3ec56e00064c/CHIM+Blog+header+1.png Further Reading - Human Challenge Trials Overview - Make it stand out In a human challenge trial, healthy, informed, consenting participants are intentionally exposed to a bacteria or virus in a safe environment. These trials can provide important insights on how to improve a vaccine or treatment. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/d2282b53-e831-465a-8e9e-767615f907fa/CHIM+Blog+photo+-+Challenge+Unit.png Further Reading - Human Challenge Trials Overview - Make it stand out Human challenge trials usually take place as inpatient studies. The participants stay in a specialized facility with healthcare support available around the clock. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/f1ed7fa4-6cd5-47b8-b20f-fad34bd85e42/CHIM+Blog+photo+-+Puzzle+pieces.png Further Reading - Human Challenge Trials Overview - Make it stand out Human challenge trials provide important insights on how well vaccines protect us, our immune responses, and how to improve a vaccine or treatment. https://images.squarespace-cdn.com/content/v1/61e8621669b86018c822d179/1de3cde6-6136-485f-87d3-32437c5a60d6/CHIM+Blog+photo+-+Informed+Consent.png Further Reading - Human Challenge Trials Overview - Make it stand out Informed consent is crucial to an ethical and safe clinical study. 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